Research Article
Influence of Overt Diabetes Mellitus on Cyclosporine Pharmacokinetics in a Canine Model
Table 1
Biochemical parameters in healthy and diabetic beagle dogs.
| Parameter | Group | Mean ± SEM | P value |
| Fasting serum glucose (mmo/L) | Healthy | | .0003 | Diabetic | | Total cholesterol (mmo/L) | Healthy | | .0279 | Diabetic | | High-density lipoprotein (mmo/L) | Healthy | | .8331 | Diabetic | | Low-density lipoprotein (mmo/L) | Healthy | | .0001 | Diabetic | | Triglyceride (mmo/L) | Healthy | | .5042 | Diabetic | | Serum creatinine (mo/L) | Healthy | | .0885 | Diabetic | | Blood urea nitrogen (mmo/L) | Healthy | | .6719 | Diabetic | |
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