Influence of Overt Diabetes Mellitus on Cyclosporine Pharmacokinetics in a Canine Model

Table 2

Compartmental pharmacokinetic parameters of cyclosporine following an intravenous administration of 5 mg/kg in healthy and diabetic beagle dogs.

Parameter	Estimate (Mean ± SEM)
	Healthy dog	Diabetic dog	𝑃 value
A (𝜇g L^-1)	3676.57 ± 857.15	2866.58 ± 419.88	.4237
B (𝜇g L^-1)	553.77 ± 92.76	738.09 ± 79.93	.1706
α (hr^-1)	0.74 ± 0.28	1.63 ± 0.36	.0477
β (hr^-1)	0.026 ± 0.008	0.094 ± 0.026	.0207
K12 (hr^-1)	0.53 ± 0.25	0.89 ± 0.22	.1404
K21 (hr^-1)	0.11 ± 0.022	0.48 ± 0.16	.0186
K10 (hr^-1)	0.13 ± 0.03	0.34 ± 0.07	.1076
V1 (L kg^-1)	1.35 ± 0.16	1.49 ± 0.22	.5669
V2 (L kg^-1)	6.95 ± 2.86	3.04 ± 0.38	.1788