Research Article
Influence of Overt Diabetes Mellitus on Cyclosporine Pharmacokinetics in a Canine Model
Table 2
Compartmental pharmacokinetic parameters of cyclosporine following an intravenous administration of 5 mg/kg in healthy and diabetic beagle dogs.
| Parameter | Estimate (Mean ± SEM) | Healthy dog | Diabetic dog | value |
| A (g L-1) | 3676.57 ± 857.15 | 2866.58 ± 419.88 | .4237 | B (g L-1) | 553.77 ± 92.76 | 738.09 ± 79.93 | .1706 | α (hr-1) | 0.74 ± 0.28 | 1.63 ± 0.36 | .0477 | β (hr-1) | 0.026 ± 0.008 | 0.094 ± 0.026 | .0207 | K12 (hr-1) | 0.53 ± 0.25 | 0.89 ± 0.22 | .1404 | K21 (hr-1) | 0.11 ± 0.022 | 0.48 ± 0.16 | .0186 | K10 (hr-1) | 0.13 ± 0.03 | 0.34 ± 0.07 | .1076 | V1 (L kg-1) | 1.35 ± 0.16 | 1.49 ± 0.22 | .5669 | V2 (L kg-1) | 6.95 ± 2.86 | 3.04 ± 0.38 | .1788 |
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