Journal of Diabetes Research / 2009 / Article / Tab 2

Research Article

Influence of Overt Diabetes Mellitus on Cyclosporine Pharmacokinetics in a Canine Model

Table 2

Compartmental pharmacokinetic parameters of cyclosporine following an intravenous administration of 5 mg/kg in healthy and diabetic beagle dogs.

ParameterEstimate (Mean ± SEM)
Healthy dogDiabetic dog value

A ( g L-1)3676.57 ± 857.152866.58 ± 419.88.4237
B ( g L-1)553.77 ± 92.76738.09 ± 79.93.1706
α (hr-1)0.74 ± 0.281.63 ± 0.36.0477
β (hr-1)0.026 ± 0.0080.094 ± 0.026.0207
K12 (hr-1)0.53 ± 0.250.89 ± 0.22.1404
K21 (hr-1)0.11 ± 0.0220.48 ± 0.16.0186
K10 (hr-1)0.13 ± 0.030.34 ± 0.07.1076
V1 (L kg-1)1.35 ± 0.161.49 ± 0.22.5669
V2 (L kg-1)6.95 ± 2.863.04 ± 0.38.1788

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