Research Article
Influence of Overt Diabetes Mellitus on Cyclosporine Pharmacokinetics in a Canine Model
Table 3
Noncompartmental pharmacokinetic parameters of cyclosporine following an intravenous administration of 5 mg/kg in healthy and diabetic beagle dogs.
| | Parameter | Estimate (Mean ± SEM) | | Healthy dog | Diabetic dog | value |
| | (g L-1) | 3680.50 ± 661.58 | 3721.28 ± 638.62 | .8801 | | MRT (hr) | 25.73 ± 3.04 | 10.6313 ± 2.35 | .0098 | | (hr L-1) | 15892.66 ± 1225.49 | 10144.39 ± 1113.72 | .0119 | | (hr L-1) | 25181.39 ± 1513.63 | 12110.47 ± 1881.94 | .0019 | | CL (L hr-1 kg-1) | 0.201 ± 0.010 | 0.457 ± 0.076 | .0019 | | (L Kg-1) | 5.12 ± 0.57 | 4.19 ± 0.45 | .2468 | | (hr-1) | 0.032 ± 0.003 | 0.106 ± 0.037 | .0125 | | (hr) | 22.56 ± 2.3042 | 9.3194 ± 2.2896 | .0125 |
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