Journal of Diabetes Research / 2009 / Article / Fig 2

Research Article

Altered Regulation of Contraction-Induced Akt/mTOR/p70S6k Pathway Signaling in Skeletal Muscle of the Obese Zucker Rat

Figure 2

Contraction-induced p70S6k phosphorylation is altered with insulin resistance. The basal (control) and contraction-induced phosphorylation of the p70S6k in Plantaris muscles from lean (LNZ) and obese (OSXZ) Zucker rats at 0, 1, and 3 hours after contractile stimulus. p70S6k (Thr389 & Thr421/Ser424) phosphorylation was determined by immunoblotting for phosphorylation on Thr389 and Thr421/Ser424. Relative abundance represents ratio of phospho to total protein. An asterisk ( ) indicates significant difference (P < .05) from the control animals and a dagger ( ) indicates a significant difference (P < .05) from the corresponding time points across animal models.

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