Altered Regulation of Contraction-Induced Akt/mTOR/p70S6k Pathway Signaling in Skeletal Muscle of the Obese Zucker Rat
Figure 4
Effects of concentric, maximal muscle contraction in situ on phosphorylation of Akt (Thr308/Ser473). The basal (control) and contraction-induced phosphorylation of the Akt in Plantaris muscles from lean (LNZ) and obese (OSXZ) Zucker rats at 0, 1, and 3 hours after HFES. Akt phosphorylation was determined by immunoblotting for Akt phosphorylation on Thr308 and Ser473. Relative abundance represents ratio of phosphor to total protein. An asterisk () indicates significant difference (P < .05) from the control n animals, and a dagger () indicates significant difference (P < .05) from corresponding time points across the animal models.
