Journal of Diabetes Research / 2009 / Article / Fig 4

Research Article

Altered Regulation of Contraction-Induced Akt/mTOR/p70S6k Pathway Signaling in Skeletal Muscle of the Obese Zucker Rat

Figure 4

Effects of concentric, maximal muscle contraction in situ on phosphorylation of Akt (Thr308/Ser473). The basal (control) and contraction-induced phosphorylation of the Akt in Plantaris muscles from lean (LNZ) and obese (OSXZ) Zucker rats at 0, 1, and 3 hours after HFES. Akt phosphorylation was determined by immunoblotting for Akt phosphorylation on Thr308 and Ser473. Relative abundance represents ratio of phosphor to total protein. An asterisk ( ) indicates significant difference (P < .05) from the control n animals, and a dagger ( ) indicates significant difference (P < .05) from corresponding time points across the animal models.

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