Journal of Diabetes Research / 2009 / Article / Tab 1

Research Article

The Roles of Streptozotocin Neurotoxicity and Neutral Endopeptidase in Murine Experimental Diabetic Neuropathy

Table 1

Effect of 3-O-methyl-glucose on Markers for Diabetic Neuropathy in Streptozotocin-treated C57Bl/6 and Swiss Webster Mice.

C57Bl/6Control (10)Diabetic (15)3-O-methyl-glucose (15)

Start weight (g)25. ± 0.726.9 ± 0.425.4 ± 0.5
End weight (g)30.6 ± 1.025.7 ± 0.8 29.6 ± 0.5
Blood glucose (mg/dL)175 ± 8582 ± 6 214 ± 27
Insulin (pM)10.6 ± 3.40.7 ± 0.3 12.8 ± 3.0
MNCV (m/sec)33.6 ± 2.221.6 ± 1.2 35.7 ± 1.6
SNCV23.2 ± 0.818.6 ±0.4 22.8 ± 0.5
Thermal response latency (sec)6.70 ± 0.4012.08 ± 0.92 7.21 ± 0.27

Swiss WebsterControl (9)Diabetic (9)3-O-methyl-glucose (9)

Start weight (g)27.8 ± 0.629.0 ± 0.727.4 ± 0.4
End weight (g)32.1 ± 1.324.6 ± 0.4 32.3 ± 1.0
Blood glucose (mg/dL)182 ± 24573 ± 27 226 ± 14
MNCV (m/sec)47.8 ± 1.238.8 ± 1.4 46.4 ± 1.7
Thermal response latency week 4 (sec)5.6 ± 0.48.8 ± 0.7 5.0 ± 0.6
Thermal response latency week 8 (sec)4.9 ± 0.47.7 ± 0.9 5.8 ± 0.4

Data are presented as the mean ± SEM. compared to control for the respective group, compared to diabetic. Parentheses indicate the number of experimental animals.

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