The Metal Chelators, Trientine and Citrate, Inhibit the Development of Cardiac Pathology in the Zucker Diabetic Rat

Table 2

Comparison of in vivo left ventricular functional parameters in lean control untreated ZDF, ZDF + trientine, and ZDF + citric acid at 32 weeks of age. Values are presented as mean ± SEM. 𝑛= 4–6 per group. * denotes 𝑃<.05 versus age-matched lean control. † denotes 𝑃<.05 versus untreated ZDF.

	Heart rate (bpm)	Cardiac output (mL/min)	Stroke volume (𝜇L)	End diastolic pressure (mmHg)	End systolic pressure (mmHg)	Max dP/dt	Min dP/dt
Lean control	291±9	38±2	121±5	7±0.4	132±7	7244±332	−7533±554
ZDF	279±7	39±3	150±9*	10±0.6*	135±7	7423±500	−6777±518
ZDF + trientine	270±12	35±4	130±9	7±0.3^†	136±11	7184±576	−7392±376
ZDF + citric acid	248±13*	31±2	122±5	7±0.5^†	129±13	6509±484	−6659±707