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Experimental Diabetes Research
Volume 2009, Article ID 715057, 9 pages
Research Article

Effect of Food Restriction on Adipose Tissue in Spontaneously Diabetic Torii Fatty Rats

1Japan Tobacco Inc., Central Pharmaceutical Research Institute, 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan
2Japan Tobacco Inc., Toxicology Research Laboratories, Central Pharmaceutical Research Institute, 23 Naganuki, Hadano, Kanagawa 257-0024, Japan

Received 24 February 2009; Accepted 8 June 2009

Academic Editor: Ryuichi Kikkawa

Copyright © 2009 Hisayo Morinaga et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Spontaneously Diabetic Torii-fa/fa (SDT fatty) rat is a new model of obese type 2 diabetes. SDT fatty rat exhibits obesity associated with hyperphagia. In this study, SDT fatty rats were subjected to pair-feeding with SDT-+/+ (SDT) rats from 6 to 22 weeks of age. The ratio of visceral fat weight to subcutaneous fat weight (V/S) decreased at 12 weeks of age in the pair-feeding rats. The intraperitoneal fat weight such as epididymal and retroperitoneal fat weight decreased, whereas mesenteric fat weight had no change. Cell size of the epididymal fat in the pair-feeding rats tended to decrease. Glucose oxidation level in epididymal fat in the pair-feeding rats at 12 weeks of age was recovered to a similar level with that in SDT rats. These results indicated that SDT fatty rat is a useful model to evaluate the functional or the morphological features in adipose tissue and develop a novel drug for antiobesity.