Dynamic Changes of Neuroskeletal Proteins in DRGs Underlie Impaired Axonal Maturation and Progressive Axonal Degeneration in Type 1 Diabetes

Figure 4

Protein expressions of activated kinases: (a) phosphorylated p42/44; (b) total p42/44; (c) phosphorylatead SAPK/JNK;. (d) phosphorylated-p38; (e) Ratio of phosphorylated / total p44 and p42 at 2-month, 7-month and 10-month duration. Phophorylation ratio was calculated by dividing phosphorylated protein level with respective total protein level. Results are means ± SD (𝑛=4). *𝑃<.05, ^**𝑃<.01, ^***𝑃<.005 and ^****𝑃<.001 versus respective control rats.

(a) Phosphorylated p42/44

(b) Total p42/44

(c) Phosphorylated SAPK/JNK

(d) Phosphorylated p38

(e) Ratio of phosphorylated p44 and p42