Cold Exposure Exacerbates the Development of Diabetic Polyneuropathy in the Rat
Figure 4
PGP 9.5 stained skin and skin fiber density. Photomicrographs showing PGP 9.5-stained sections. Pictures were taken at , scale bar m. ND RT: nondiabetic room temperature, ND C: nondiabetic cold, D RT: diabetic room temperature, D C: diabetic cold. Graph of IENF densities shows that diabetic animals exposed to a cold environment had the lowest IENF densities ( each control group, each diabetic group). The data suggest that diabetic animals exposed to a cold environment have the smallest number of stained nerve fibers in the skin. White arrows indicate PGP 9.5-positive fibers. Mean ± SEM. for the interaction term.
