Review Article
Therapeutics of Diabetes Mellitus: Focus on Insulin Analogues and Insulin Pumps
Table 3
CSII therapy in pediatric patients.
| Current indications |
| Recurrent severe hypoglycemia | Wide fluctuations in blood glucose levels regardless of HbA1c | Suboptimal diabetes control | Microvascular complications and/or risk factors for macrovascular complications | Good metabolic control but insulin regimen that compromises lifestyle (e.g., competitive athletes and needle phobia) | Adolescents with eating disorders | Children and adolescents with a pronounced dawn phenomenon | Ketosis-prone individuals |
| Advantages of CSII compared with MDI in children |
| Easier and convenient adjustment of bolus insulin dose and nocturnal basal insulin dose | Greater accuracy of insulin dosage | Easier management of infectious illnesses and hyperglycemic episodes | Quality of life improvement | Less injections Less anxiety better compliance | Flexibility of everyday activities |
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