Peroxynitrite Mediates Diabetes-Induced Endothelial Dysfunction: Possible Role of Rho Kinase Activation

<table>FeTPPs improves diabetes-impaired coronary endothelial-dependent vasorelaxation<i>. </i>Concentration-response curves for the effect of ACh for coronary arteries from control, diabetic, FeTPPs-treated control, and FeTPPs-treated diabetic rats at 4 weeks (<i>n</i> = 6 in each group). ACh <svg height="15.4" id="M44" style="vertical-align:-3.3907pt" version="1.1" viewbox="0 0 36.037498 15.4" width="36.037498" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> value from diabetic vessels was significantly lower than control. Cotreatment with FeTPPs improved <svg height="15.4" id="M45" style="vertical-align:-3.3907pt" version="1.1" viewbox="0 0 36.037498 15.4" width="36.037498" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> value from diabetic vessels but did not affect treated controls. Values are expressed as means ± SEM, <svg height="17.825001" id="M46" style="vertical-align:-3.27605pt" version="1.1" viewbox="0 0 60.987499 17.825001" width="60.987499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus control.</table>

Journal of Diabetes Research

fig1

Figure 1

Figure 1: Peroxynitrite Mediates Diabetes-Induced Endothelial Dysfunction: Possible Role of Rho Kinase Activation 