Peroxynitrite Mediates Diabetes-Induced Endothelial Dysfunction: Possible Role of Rho Kinase Activation
Figure 5
Inhibiting peroxynitrite or Rho kinase restored NO production in BAEC. High glucose (HG, 25 mM) significantly reduced NO production (50%) as measured by NO analyzer in BAEC cultures compared to normal glucose (NG, 5 mM). Cotreatment with FeTPPs (Fe, 2.5 M) or with the specific Rho-kinase inhibitor Y26732 (Y, 1 M) restored NO production in high-glucose-maintained cultures. () Values are expressed as means ± SEM, versus control.
