Wound Healing in Mice with High-Fat Diet- or ob Gene-Induced Diabetes-Obesity Syndromes: A Comparative Study
Figure 2
Wound closure and systemic effects of wounding. (a) 5-day wounds in CD-fed, HFD-fed and ob/ob mice (left panel). Distances of neoepithelia in cross-sectional areas of 5-day and 7-day wounds of CD-fed, HFD-fed and ob/ob mice (right panels). (b) Histologies showing wound neoepithelia of CD, HFD or ob/ob mice as indicated. Scale bars = 500 μm. The epithelial margins are indicated by a yellow line. Panel: areas of wound margin neoepithelia in CD, HFD and ob/ob mice. ** versus CD-fed mice. Bars indicate the mean ± SD obtained from 8 wounds () from 4 individual animals (). (c) Serum insulin, (d) Leptin and (e) TNF-α levels in CD-fed, HFD-fed or ob/ob mice before wounding and during different days of healing as indicated. **; * versus CD-fed mice. Each single experimental time point depicts the mean ± SD obtained from 4 individual animals ().
