Peripheral 5-HT<sub>
					1A
				</sub> and 5-HT<sub>
					7
				</sub>
 Serotonergic Receptors Modulate Parasympathetic Neurotransmission in Long-Term Diabetic Rats

<table>Changes in heart rate (ΔHR) evoked by electrical stimulation of the peripheral end of the right vagus in atenolol (1 mg/kg) pretreated diabetic pithed rats after i.v. administration of a bolus of 1 mL/kg of saline solution, 5, 50, and 200 <i>μ</i>g/kg of 5-carboxamidotryptamine (5-CT; <svg height="10.925" id="M52" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 10.925" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> for each dose), <i>α</i>-methyl-5-HT (<i>α</i>-m-5-HT; 150 <i>μ</i>g/kg), or 1-phenylbiguanide (1-PBG; 150 <i>μ</i>g/kg). *<svg height="11.375" id="M53" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 50.549999 11.375" width="50.549999" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.112)"><path d="M619 482q0 -69 -40.5 -119t-96 -72.5t-118.5 -26.5h-44l-70 20l-31 -151q-14 -67 0.5 -83t89.5 -22l-5 -28h-287l8 28q65 7 81.5 22t29.5 83l79 398q12 56 0.5 70.5t-78.5 20.5l7 28h255q108 0 164 -43t56 -125zM524 478q0 141 -146 141q-25 0 -47 -8q-16 -6 -20.5 -13.5
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q0 -76 10 -138.5t37 -107.5t69 -45q32 0 55.5 25t35.5 68.5t17.5 91.5t5.5 105t-5.5 105.5t-18 92t-36 68t-56.5 24.5z" id="x30"></path></g><g transform="matrix(.017,-0,0,-.017,42.321,11.112)"><path d="M153 550l-26 -186q79 31 111 31q90 0 141.5 -51t51.5 -119q0 -93 -89 -166q-85 -69 -173 -71q-32 0 -61.5 11.5t-41.5 23.5q-18 17 -17 34q2 16 22 33q14 9 26 -1q61 -50 124 -50q60 0 93 43.5t33 104.5q0 69 -41.5 110t-121.5 41q-53 0 -102 -20l38 305h286l6 -8
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</svg> compared with saline.</table>

Journal of Diabetes Research

fig3

Figure 3

Figure 3: Peripheral 5-HT<sub>
					1A
				</sub> and 5-HT<sub>
					7
				</sub>
 Serotonergic Receptors Modulate Parasympathetic Neurotransmission in Long-Term Diabetic Rats 

Figure 3 | Peripheral 5-HT
					1A
				 and 5-HT
					7
				
 Serotonergic Receptors Modulate Parasympathetic Neurotransmission in Long-Term Diabetic Rats 

Journal of Diabetes Research

Peripheral 5-HT 1A and 5-HT 7 Serotonergic Receptors Modulate Parasympathetic Neurotransmission in Long-Term Diabetic Rats

Figure 3

Peripheral 5-HT_1A and 5-HT₇ Serotonergic Receptors Modulate Parasympathetic Neurotransmission in Long-Term Diabetic Rats