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Experimental Diabetes Research
Volume 2010, Article ID 761715, 8 pages
http://dx.doi.org/10.1155/2010/761715
Clinical Study

C-Reactive Protein and Gamma-Glutamyltransferase Concentrations in Relation to the Prevalence of Type 2 Diabetes Diagnosed by Glucose or HbA1c Criteria in Chinese Adults in Qingdao, China

1Department of Epidemiology and Health Statistics, Shandong University, Jinan 250012, China
2Department of Non-Communicable Disease Prevention, Qingdao Municipal Centre for Disease Control and Prevention, no. 175, Shandong Road, Qingdao 266071, China
3Department of Public Health, University of Helsinki, 00014 Helsinki, Finland
4Diabetes Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, 00014 Helsinki, Finland
5Qingdao Endocrinology and Diabetes Hospital, 266071 Qingdao, China
6Hong Kong Institute of Diabetes and Obesity, Hong Kong, China

Received 13 August 2010; Revised 12 October 2010; Accepted 12 October 2010

Academic Editor: Giuseppe Paolisso

Copyright © 2010 J. Ren et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aims. To investigate the association of C-reactive protein (CRP) and gamma glutamyltransferase (GGT) concentrations with newly diagnosed diabetes defined by either glucose or HbA1c criteria in Chinese adults. Methods. A population-based cross-sectional study was conducted in 2006. Data from 1167 men and 1607 women aged 35–74 years were analyzed. Diabetes was defined according to either glucose or HbA1c criteria alone. Results. Compared with nondiabetes, multivariate-adjusted OR (95%CI) was 1.13 (0.90,1.42) in men and 1.21 (1.00,1.45) in women for CRP and 1.42 (1.18,1.72) and 1.57 (1.31,1.87) for GGT, respectively. Neither CRP nor GGT was associated with the presence of diabetes defined by the HbA1c criterion. Conclusions. The effect of elevated CRP on diabetes defined by the glucose criterion was mediated through obesity, but elevated GGT was an independent risk factor for diabetes in this Chinese population. None of the two was, however, associated with the elevated HbA1c concentrations.