Modulation of the Cellular Expression of Circulating Advanced Glycation End-Product Receptors in Type 2 Diabetic Nephropathy

Table 1

Renal and metabolic parameters in an experimental model of metabolic syndrome and type 2 diabetes the dbdb mouse followed from weeks 10 to 20 of age. Dbh: non diabetic control mice, dbdb: diabetic mice.

	𝑁	Plasma glucose (mmol/L)	Total cholesterol (mmol/L)	Circulating AGE (μmol/mol lysine)	Creatinine clearance (ml/min/m^2)	Albumin excretion rate (μg/24 hr)	Kidney to body; weight ratio; (%  ×10^−3))
dbh Low AGE	10	19.6±4.9	1.5±0.2	304.1±106.8	17.2±1.4	226.5±34.6	1.13±0.16
dbh High AGE	10	18.8±5.3	1.4±0.2	357.3±88.2	24.2±6.3^§	151.0±12.9	1.22±0.13
dbdb Low AGE	10	38.0±8.5^$	1.5±0.5	353.3±136.1	20.1±15.4	2608.0±791.1^$	1.62±0.27^$
dbdb High AGE	10	35.7±6.3^$	1.8±0.5^$	284.8±69.1	13.4±8.0^#$	2334.3±520.2^$	1.63±0.24^$

^§𝑃<.05 versus dbh Low AGE, ^#𝑃<.05 versus dbdb Low AGE, ^$𝑃<.05 versus corresponding dbh group.