Neural Degeneration in the Retina of the Streptozotocin-Induced Type 1 Diabetes Model

Figure 1

Expression of angiotensin II type 1 receptor and synaptophysin in the mouse retina. Expression of AT1R (green) in the normal retina (A–C). The boxed area in A is magnified in B and C (merged in C), and the boxed areas in C are magnified in the insets of C. AT1R is coexpressed with synaptophysin (pink), a presynaptic vesicle protein, in the IPL (arrow in the upper inset of C) and OPL (arrows in B and the lower inset of C). AT1R, angiotensin II type 1 receptor; GCL, ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer [28].