Research Article
Diabetic Nephropathy Amelioration by a Low-Dose Sitagliptin in an Animal Model of Type 2 Diabetes (Zucker Diabetic Fatty Rat)
Table 4
Scoring and distribution of tubular lesions in lean control and obese diabetic ZDF rats kidneys at the final time, 26 weeks of age (6 weeks of vehicle or sitagliptin treatment).
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aLean control (vehicle) versus obese diabetic (vehicle) rats; bdiabetic SITA-treated versus diabetic untreated rats. One, two, or three letters for , , and , respectively. TMB: tubular basement membrane; IFTA: interstitial fibrosis and tubular atrophy. Scoring was defined according to the extension occupied by the lesion (% area of the tubulus): normal: <25%; mild: 25–50%; moderate: 50–75%; severe: >75%. SITA, sitagliptin. |