Insulin Receptor Substrate 2 Expression and Involvement in Neuronal Insulin Resistance in Diabetic Neuropathy
Figure 4
Total IRS2 and IR protein levels in mouse lumbar DRG. Protein was harvested from adult mouse DRG culture from diabetic ob/ob and nondiabetic mice. Western blots were performed using antibodies that recognized total IRS2 (a) or IR β subunit levels (b). In both cases protein levels were normalized to actin. (a) Total IRS2 levels were slightly decreased in diabetic ob/ob mice although this trend was not statistically significant (). for nondiabetic mice and for diabetic mice. (b) IR β subunit protein levels were not statistically different between diabetic and nondiabetic mice (). for nondiabetic mice and for diabetic mice.
