Development of a Nongenetic Mouse Model of Type 2 Diabetes

Figure 1

Food intake. (a) Food intake (A; g⋅mouse⁻¹⋅d⁻¹) before beginning STZ injections (end of wk 5) and each week until the end of the trial (9 wks) and (b) interaction of diet × STZ treatment on food intake. Male, retired breeder (6 mo.) C57BL/6 mice were used for this study. Before STZ injections 𝑁=8 and after STZ injections 𝑁=5–8. Values represent mean ± SEM. ^#𝑃<0.05 versus respective LFD group, ^‡𝑃=0.07 versus respective LFD group.

(a) Food intake

(b) Food intake: interaction of diet × STZ treatment