Development of a Nongenetic Mouse Model of Type 2 Diabetes

Figure 7

Insulin tolerance test: (a) Fasting blood glucose concentrations at baseline and 15, 30, 60, and 120 min post-insulin loading via i.p. injection (0.75U⋅kg⁻¹BW), (b) interactions of diet × STZ treatment on total AUC calculated from insulin tolerance test data. Male, retired breeder (6 mo.) C57BL/6 mice were used for this study. Values represent mean ± SEM (𝑁=5–8). ^#𝑃<0.05 versus respective LFD group.

(a) Insulin tolerance test blood glucose levels

(b) Insulin tolerance test total AUC