Development of a Nongenetic Mouse Model of Type 2 Diabetes

Figure 8

Interactions of diet × STZ treatment on blood lipid profile and hormones on final day of trial. (a) Whole blood total cholesterol, (b) whole blood HDL, (c) whole blood triglycerides, and (d) serum insulin levels. Male, retired breeder (6 mo.) C57BL/6 mice were used for this study. Values represent mean ± SEM (𝑁=5–8). *𝑃<0.05 versus respective control, ^#𝑃<0.05 versus respective LFD group, ^‡𝑃=0.07 to 0.08 versus respective LFD group, ^†𝑃=0.06 to 0.07 versus respective control.

(a) Whole blood total cholesterol

(b) Whole blood HDL

(c) Whole blood triglycerides

(d) Serum insulin