Exercise Increases Insulin Content and Basal Secretion in Pancreatic Islets in Type 1 Diabetic Mice
Figure 4
Islet cell composition. (a) Representative islets from each group are shown. In the healthy control (left image), insulin-positive β-cells (green) are the most common cell type. However, in both diabetic groups, [diabetic (center image) and diabetic + exercise (left image)] glucagon-positive alpha cells were the major cell type. (Scale bar: 100 μm.) (b) Graph showing the relative proportion of three major types of endocrine cells in the islets from each group. There was no significant difference in the cell composition between the sedentary diabetic and exercised diabetic groups (NS). *Indicates significant difference () in β-cells (green) versus α-cells (red) and δ-cells (blue) in the control. #Indicates significant difference () in β-cells (green) between control and diabetic groups.
