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Experimental Diabetes Research
Volume 2011, Article ID 486316, 11 pages
Research Article

Maternal Manganese Restriction Increases Susceptibility to High-Fat Diet-Induced Dyslipidemia and Altered Adipose Function in WNIN Male Rat Offspring

1Division of Endocrinology and Metabolism, National Institute of Nutrition, Hyderabad 500 604, India
2Department of Orthopaedic Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
3National Centre for Laboratory Animal Sciences, National Institute of Nutrition, Hyderabad 500 604, India
4Food Chemistry Division, National Institute of Nutrition, Hyderabad 500 604, India

Received 22 June 2011; Accepted 17 July 2011

Academic Editor: Giuseppe Paolisso

Copyright © 2011 Manisha Ganeshan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Growth in utero is largely a reflection of nutrient and oxygen supply to the foetus. We studied the effects of Mn restriction per se, maternal Mn restriction, and postnatal high-fat feeding in modulating body composition, lipid metabolism and adipocyte function in Wistar/NIN (WNIN) rat offspring. Female weanling, WNIN rats received ad libitum for 4 months, a control or Mn-restricted diet and were mated with control males. Some restricted mothers were rehabilitated with control diet from conception (MnRC) or parturition (MnRP), and their offspring were raised on control diet. Some restricted offspring were weaned onto control diet (MnRW), while others continued on restricted diet throughout (MnR). A set of offspring from each group was fed high-fat diet from 9 months onwards. Body composition, adipocytes function, and lipid metabolism were monitored in male rat offspring at regular intervals. Maternal manganese restriction increased the susceptibility of the offspring to high-fat-induced adiposity, dyslipidaemia, and a proinflammatory state but did not affect their glycemic or insulin status.