Frequent Loss of Genome Gap Region in 4p16.3 Subtelomere in Early-Onset Type 2 Diabetes Mellitus

Figure 3

The extent of copy number losses within 1.3-Mb 4p16.3 subtelomeric region in 13 early-onset T2DM patients revealed by high-density oligonucleotide tiling microarray. Dark horizontal bars represent extent of copy number loss region in each patient revealed by Agilent custom tiling array. Genome structure of the 13 patients is aligned as horizontal bars from genome position 550,000 (left) to position 1,850,000 (right). Hatched region at position 1,423,147–1,478,646 represents genome gap-177 region. Gray regions represent proximal ends of stretch where copy number status was not inferred due to presence of multiple low copy repeats. Upper map shows ideogram of chromosome 4 and the positions of putative genes in 4p16.3 region described in Database of Genomic Variants (http://projects.tcag.ca/variation/). Position is given relative to NCBI Build 35 for the chromosome 4.