Frequent Loss of Genome Gap Region in 4p16.3 Subtelomere in Early-Onset Type 2 Diabetes Mellitus

Table 1

Putative genes located within 1.3-Mb region in 4p16.3 subtelomere.

Start	End	Cytogenetic location	Symbol	Description	Model evidence
609,373	654,571	4p16.3	PDE6B	Phosphodiesterase 6B, cGMP-specific, rod, beta (congenital stationary night blindness 3, autosomal dominant)	Best RefSeq
656,225	658,122	4p16.3	ATP5I	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit E	Best RefSeq
661,711	665,817	4p16.3	MYL5	Myosin, light chain 5, regulatory	Best RefSeq
665,618	672,973	4p16.3	MFSD7	Major facilitator superfamily domain containing 7	mRNA
689,573	754,428	4p16.3	PCGF3	Polycomb group ring finger 3	Best RefSeq
719,829	721,544	4p16.3	LOC100128084	Hypothetical protein LOC100128084	mRNA
764,588	765,632	4p16.3	LOC100129917	Hypothetical protein LOC100129917	mRNA
768,745	809,945	4p16.3	CPLX1	Complexin 1	mRNA
833,065	916,174	4p16.3	GAK	Cyclin G associated kinase	mRNA
916,262	942,444	4p16.3	TMEM175	Transmembrane protein 175	Best RefSeq
942,675	957,344	4p16.3	DGKQ	Diacylglycerol kinase, theta 110 kDa	Best RefSeq
962,861	977,224	4p16.3	SLC26A1	Solute carrier family 26 (sulfate transporter), member 1	Best RefSeq
970,785	988,317	4p16.3	IDUA	Iduronidase, alpha-L-	mRNA
995,610	1,010,686	4p16.3	FGFRL1	Fibroblast growth factor receptor-like 1	Best RefSeq
1,044,654	1,045,386	4p16.3	LOC100132787	Hypothetical protein LOC100132787	mRNA
1,055,269	1,097,350	4p16.3	RNF212	Ring finger protein 212	Best RefSeq
1,116,050	1,129,814	4p16.3	LOC100133135	Hypothetical protein LOC100133135	Protein
1,135,541	1,135,957	4p16.3	FLJ35816	FLJ35816 protein	Protein
1,149,293	1,149,712	4p16.3	LOC100131106	Hypothetical protein LOC100131106	Protein
1,150,723	1,156,597	4p16.3	SPON2	Spondin 2, extracellular matrix protein	Best RefSeq
1,184,431	1,185,198	4p16.3	LOC100130872	Hypothetical protein LOC100130872	mRNA
1,195,228	1,232,908	4p16.3	CTBP1	C-terminal binding protein 1	Best RefSeq
1,234,177	1,236,616	4p16.3	C4orf42	Chromosome 4 open reading frame 42	Best RefSeq
1,273,672	1,323,925	4p16.3	MAEA	Macrophage erythroblast attacher	Best RefSeq
1,331,104	1,371,732	4p16.3	KIAA1530	KIAA1530	mRNA
1,375,340	1,379,782	4p16.3	CRIPAK	Cysteine-rich PAK1 inhibitor	mRNA
1,380,072	1,392,453	4p16.3	NKX1-1	NK1 homeobox 1	Protein
1,484,196	1,519,086	4p16.3	LOC100133199	Similar to RE32881p	mRNA
1,611,605	1,655,516	4p16.3	FAM53A	Family with sequence similarity 53, member A	Best RefSeq
1,664,325	1,683,828	4p16.3	SLBP	Stem-loop (histone) binding protein	Best RefSeq
1,687,477	1,692,882	4p16.3	TMEM129	Transmembrane protein 129	Best RefSeq
1,693,062	1,716,696	4p16.3	TACC3	Transforming, acidic coiled-coil containing protein 3	Best RefSeq
1,765,421	1,780,396	4p16.3	FGFR3	Fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)	Best RefSeq
1,784,558	1,827,772	4p16.3	LETM1	Leucine zipper-EF-hand containing transmembrane protein 1	Best RefSeq