High Glucose Increases Metallothionein Expression in Renal Proximal Tubular Epithelial Cells

Figure 1

MT-1/-2 expression in the kidney. Diabetes was induced by injection of streptozotocin, and kidneys were obtained at 1 (a and d), 2 (b and e), or 8 (c and f) weeks after inducing diabetes. Immunofluorescent staining was performed as described in Materials and Methods. MT was strongly expressed in the renal cortex of diabetic rats (d, e, f) and hardly expressed in control rats (a, b, c). The expression of MT-1/-2 was greater at week 8 than at weeks 1 and 2 after diabetes induction. Scale bar: 100 μm.