Table of Contents Author Guidelines Submit a Manuscript
Experimental Diabetes Research
Volume 2011, Article ID 692536, 8 pages
http://dx.doi.org/10.1155/2011/692536
Research Article

The Myocyte Expression of Adiponectin Receptors and PPARδ Is Highly Coordinated and Reflects Lipid Metabolism of the Human Donors

Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tübingen and German Center for Diabetes Research (DZD e.V.), Tübingen, Germany

Received 3 September 2010; Revised 21 December 2010; Accepted 5 January 2011

Academic Editor: Toshiyasu Sasaoka

Copyright © 2011 Anna-Maria Ordelheide et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. U. Julius, “Influence of plasma free fatty acids on lipoprotein synthesis and diabetic dyslipidemia,” Experimental and Clinical Endocrinology and Diabetes, vol. 111, no. 5, pp. 246–250, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Delarue and C. Magnan, “Free fatty acids and insulin resistance,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 10, no. 2, pp. 142–148, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Luquet, C. Gaudel, D. Holst et al., “Roles of PPAR delta in lipid absorption and metabolism: a new target for the treatment of type 2 diabetes,” Biochimica et Biophysica Acta, vol. 1740, no. 2, pp. 313–317, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. T. Yamauchi, J. Kamon, Y. Minokoshi et al., “Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase,” Nature Medicine, vol. 8, no. 11, pp. 1288–1295, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. E. Tomas, T. S. Tsao, A. K. Saha et al., “Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation,” Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 25, pp. 16309–16313, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Hug, J. Wang, N. S. Ahmad, J. S. Bogan, T. S. Tsao, and H. F. Lodish, “T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 28, pp. 10308–10313, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Staiger, S. Kaltenbach, K. Staiger et al., “Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism,” Diabetes, vol. 53, no. 9, pp. 2195–2201, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. H. Staiger, N. Stefan, F. Machicao, A. Fritsche, and H. U. Häring, “PPARGC1A mRNA levels of in vitro differentiated human skeletal muscle cells are negatively associated with the plasma oleate concentrations of the donors,” Diabetologia, vol. 49, no. 1, pp. 212–214, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Staiger, C. Haas, J. Machann et al., “Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-δ and is of metabolic relevance in humans,” Diabetes, vol. 58, no. 3, pp. 579–589, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Krützfeldt, C. Kausch, A. Volk et al., “Insulin signaling and action in cultured skeletal muscle cells from lean healthy humans with high and low insulin sensitivity,” Diabetes, vol. 49, no. 6, pp. 992–998, 2000. View at Google Scholar · View at Scopus
  11. N. Stefan, F. Machicao, H. Staiger et al., “Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat,” Diabetologia, vol. 48, no. 11, pp. 2282–2291, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. N. Stefan, C. Thamer, H. Staiger et al., “Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention,” Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 5, pp. 1827–1833, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Thamer, J. Machann, N. Stefan et al., “Variations in PPARD determine the change in body composition during lifestyle intervention: a whole-body magnetic resonance study,” Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 4, pp. 1497–1500, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Tsuchida, T. Yamauchi, Y. Ito et al., “Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity,” Journal of Biological Chemistry, vol. 279, no. 29, pp. 30817–30822, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. N. Stefan, K. Kantartzis, and H. U. Häring, “Causes and metabolic consequences of fatty liver,” Endocrine Reviews, vol. 29, no. 7, pp. 939–960, 2008. View at Publisher · View at Google Scholar · View at Scopus