Treatment of Streptozotocin-Induced Diabetic Rats with Alogliptin: Effect on Vascular and Neural Complications

Table 2

Effect of treatment of streptozotocin-diabetic rats with alogliptin on serum thio barbituric acid reactive substances, triglycerides, free fatty acids, cholesterol and dipeptidyl peptidase-IV activity.

Determination	Control; (11)	Diabetic; (12)	Diabetic + Alogliptin; (9)
TBARS (μg/mL)	0.78 ± 0.07	1.07 ± 0.06^a	0.93 ± 0.12
Triglycerides (mg/dL)	25 ± 3	206 ± 27^a	225 ± 46^a
Free fatty acids (mmol/L)	0.11 ± 0.03	0.56 ± 0.07^a	0.41 ± 0.11^a
Cholesterol (mg/dL)	82 ± 13	223 ± 38^a	175 ± 35^a
Dipeptidyl peptidase-IV; activity (ng/mL)	24.0 ± 3.0	35.4 ± 5.1	18.3 ± 3.4^b

Data are presented as the mean ± SEM. ^aP < 0.05 compared to control; ^bP < 0.05 compared to diabetic. Parentheses indicate the number of experimental animals.