TGR5: A Novel Target for Weight Maintenance and Glucose Metabolism

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td align="left">Receptor</td><td align="center">FXR</td><td align="center">TGR5</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td align="left">Ligands*</td><td align="center">CDCA &gt; LCA, DCA &gt; CA</td><td align="center">LCA &gt; DCA &gt; CDCA &gt; CA</td></tr><tr><td align="left">Liver cell expression</td><td align="center">Hepatocyte, stellate cell, Sinusoid endothelial cell</td><td align="center">Sinusoid endothelial cell<br/>Kupffer cell, hepatocyte</td></tr><tr><td align="left">Functions in liver</td><td align="center">BA metabolism, antiapoptosis<br/>Anti-inflammatory response,<br/>liver regeneration,<br/>HCC suppression</td><td align="center">Suppress LPS response, <br/>glucagon expression,<br/>energy metabolism,<br/>liver inflammation, and HCC?</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td>
              *CDCA: chenodeoxycholic acid; CA: cholic acid; DCA: deoxycholic acid; LCA: lithocholic acid; LPS: lipopolysaccharide.<br/></td></tr></table>

Comparison between two BA receptors in liver.

Journal of Diabetes Research

tab1

Table 1

Table 1: TGR5: A Novel Target for Weight Maintenance and Glucose Metabolism 