Review Article
From Theory to Clinical Practice in the Use of GLP-1 Receptor Agonists and DPP-4 Inhibitors Therapy
| | GLP-1 receptor agonists | DPP-4 inhibitors |
| Administration | Injection | Oral | GLP-1 concentration | Pharmacologic | Physiologic | Insulin Secretion | ++ | + | Glucagon secretion | − − | − − | Action | ↑ GLP-1 | ↑ GLP-1 and GIP | Gastric emptying | − | ± | Weight loss | ++ | = | β-cell protection | ++* | ++* | Immunogenicity | +° | − | Nausea and vomiting | + | − |
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*In animal model.
°Not similar for different GLP-1 receptor agonists according to their homology to native peptide.
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