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Experimental Diabetes Research
Volume 2011, Article ID 907496, 5 pages
http://dx.doi.org/10.1155/2011/907496
Research Article

The Effect of Metformin on the Myocardial Tolerance to Ischemia-Reperfusion Injury in the Rat Model of Diabetes Mellitus Type II

1Institute of Endocrinology, Almazov Federal Heart, Blood and Endocrinology Centre, Akkuratova Street 2, St. Petersburg 197341, Russia
2Institute of Experimental Medicine, Almazov Federal Heart, Blood and Endocrinology Centre, Akkuratova Street 2, St. Petersburg 197341, Russia
3Department of Pathophysiology, St. Petersburg Pavlov State Medical University, Lev Tolstoy Street 6/8, St. Petersburg 197022, Russia

Received 22 March 2011; Accepted 21 April 2011

Academic Editor: N. Cameron

Copyright © 2011 Ekaterina Kravchuk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In recent years, evidence has been accumulated that metformin, an antidiabetic drug in the biguanide class, in addition to its well-recognized glucose-lowering effect, can also reduce cardiovascular mortality in the patients with type 2 diabetes mellitus (T2DM). Besides, there are a few experimental studies on the possibility of the direct anti-ischemic effect of the drug in both type 1 diabetes mellitus and T2DM. In our study, myocardial tolerance to ischemia in rats with neonatal streptozotocin T2DM was investigated using the model of global ischemia-reperfusion of the isolated perfused heart. Metformin was administered i.p. at a dose of 200 mg/kg/day for 3 days prior to isolated heart perfusion. The results showed that both the infarct size and postischemic recovery of left ventricular function were not different between controls and metformin-treated animals. At the same time, the infarct size in the T2DM animals was significantly lower than that in the controls (24.4 ± 7.6% versus 45.0 ± 10.4%, resp., ), indicative of the metabolic preconditioning in T2DM. It follows that the protocol of metformin administration used in this study had not elicited cardioprotective effect in animals with T2DM so that the different mechanism(s) may underlie the beneficial effect of metformin on cardiovascular complications in patients with T2DM which, however, would need further investigation.