A Novel EPO Receptor Agonist Improves Glucose Tolerance via Glucose Uptake in Skeletal Muscle in a Mouse Model of Diabetes
Figure 2
Single dose of CNTO 530 improves glucose tolerance and increases hemoglobin levels in DIO mice. (a) DIO mice () were dosed IV with CNTO 530 (▿0.3 mg/kg) or PBS (■), and an IPGTT was done after 14 days. (b) IPGTT was done at various days following a single dose of CNTO 530 (0.3 mg/kg). The data were analyzed to determine the area under the curve (AUC) for CNTO 530-treated (▿) and PBS-treated (■) groups (). The AUC is plotted versus time. (c) The hemoglobin (g/dL) measured at various times following a single dose of CNTO 530 (0.3 mg/kg) was plotted versus time. The results are presented as mean ± SEM. *indicates a P value < .05. **indicates a P value <.01. ***indicates a P value < .005.
