A Novel EPO Receptor Agonist Improves Glucose Tolerance via Glucose Uptake in Skeletal Muscle in a Mouse Model of Diabetes
Figure 4
Dose response of epo receptor agonists. (a) Increasing concentrations of darbepoetin-α (0.03♦, 0.1▾, 0.3▲) or PBS (■) were dosed IV to DIO mice (). Seven days after dosing, an IPGTT was completed. (b) The same experiment described in A was completed with epoetin-α () at day 5 ⬤, darbepoetin () at day 7 ■, and CNTO 530 () at day 14 ○. The reduction in AUC was calculated for each molecule and was plotted versus the U/kg of Epo receptor agonist.
