Targeted Proteomics of Isolated Glomeruli from the Kidneys of Diabetic Rats: Sorbin and SH3 Domain Containing 2 Is a Novel Protein Associated with Diabetic Nephropathy

Table 1

Biological parameters from OLETF and LETO rats at 27 and 38 weeks of age.

	OLETF; (𝑛=10)	LETO; (𝑛=10)	𝑃 value	OLETF; (𝑛=10)	LETO; (𝑛=10)	𝑃 value
	27 weeks			38 weeks
Body weight (g)	642±40.9	491±34.6	<0.0001	621±69.4	580±80.7	0.2089
Food intake (g/day)	34.9±6.1	19.1±1.5	<0.0001	39.3±6.1	29.7±2.0	<0.0001
Kidney-to-body weight ratio (%)	0.703±0.10	0.597±0.054	0.0091	0.780±0.12	0.592±0.050	0.0008
Fasting plasma glucose (mg/dL)	183±58.9	135±34.2	00388	248±53.6	129±25.3	<0.0001
Hemoglobin A1c (%)	4.4±0.85	3.3±0.11	0.0021	5.7±1.2	3.3±0.18	0.0001
Total cholesterol (mg/dL)	123±23.1	97.4±9.5	0.0081	153±34.6	101±9.37	0.0009
Creatinine (mg/dL)	0.24±0.04	0.36±0.04	<0.0001	0.33±0.05	0.46±0.1	0.0031
Urinary protein-to-creatinine ratio (mg/mg)	2.73±2.10; (𝑛=5)^∗	0.60±0.08; (𝑛=5)^∗	<0.0001	5.65±2.36; (𝑛=5)^∗	0.94±0.38; (𝑛=5)^∗	<0.0001

Values are expressed as the mean ± SD.
*Urinary specimens were obtained from 5 rats per group to measure urinary protein and creatinine levels.
OLETF: Otsuka Long-Evans Tokushima Fatty, LETO: Long-Evans Tokushima Lean.