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Experimental Diabetes Research
Volume 2012, Article ID 108163, 7 pages
http://dx.doi.org/10.1155/2012/108163
Research Article

Neonatally Induced Mild Diabetes in Rats and Its Effect on Maternal, Placental, and Fetal Parameters

1Laboratory of Experimental Research in Gynecology and Obstetrics, Department of Gynecology and Obstetrics, Botucatu Medical School, Universidade Estadual Paulista (Unesp), Distrito Rubião Júnior 18618000 s/n, Botucatu, SP, Brazil
2Institute of Biological and Health Sciences, University Center of Araguaia, Mato Grosso Federal University (UFMT), Rodovia BR-070, Km 5, 78600-000 Barra do Garças, MG, Brazil

Received 9 February 2012; Revised 10 April 2012; Accepted 24 April 2012

Academic Editor: N. Cameron

Copyright © 2012 Yuri Karen Sinzato et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. R. Mathiesen, L. Ringholm, and P. Damm, “Stillbirth in diabetic pregnancies,” Best Practice and Research, vol. 25, no. 1, pp. 105–111, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Higgins, P. Felle, E. E. Mooney, J. Bannigan, and F. M. McAuliffe, “Stereology of the placenta in type 1 and type 2 diabetes,” Placenta, vol. 32, no. 8, pp. 564–569, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. N. Vitoratos, N. Vrachnis, G. Valsamakis, K. Panoulis, and G. Creatsas, “Perinatal mortality in diabetic pregnancy,” Annals of the New York Academy of Sciences, vol. 1205, pp. 94–98, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. U. J. Eriksson, “Congenital anomalies in diabetic pregnancy,” Seminars in Fetal and Neonatal Medicine, vol. 14, no. 2, pp. 85–93, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. U. Simeoni and D. J. Barker, “Offspring of diabetic pregnancy: long-term outcomes,” Seminars in Fetal and Neonatal Medicine, vol. 14, no. 2, pp. 119–124, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Balsells, A. García-Patterson, I. Gich, and R. Corcoy, “Maternal and fetal outcome in women with type 2 versus type 1 diabetes mellitus: a systematic review and metaanalysis,” Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 11, pp. 4284–4291, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Plagemann, T. Harder, and J. Dudenhausen, “The diabetic pregnancy, macrosomia, and perinatal nutritional programming,” Nestle Nutrition Workshop Series, vol. 61, pp. 91–102, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Jawerbaum and V. White, “Animal models in diabetes and pregnancy,” Endocrine Reviews, vol. 31, no. 5, pp. 680–701, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. I. López-Soldado and E. Herrera, “Different diabetogenic response to moderate doses of streptozotocin in pregnant rats, and its long-term consequences in the offspring,” Experimental Diabesity Research, vol. 4, no. 2, pp. 107–118, 2003. View at Google Scholar · View at Scopus
  10. G. T. Volpato, D. C. Damasceno, M. V. C. Rudge, C. R. Padovani, and I. M. P. Calderon, “Effect of Bauhinia forficata aqueous extract on the maternal-fetal outcome and oxidative stress biomarkers of streptozotocin-induced diabetic rats,” Journal of Ethnopharmacology, vol. 116, no. 1, pp. 131–137, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. M. V. C. Rudge, D. C. Damasceno, G. T. Volpato, F. C. G. Almeida, I. M. P. Calderon, and I. P. Lemonica, “Effect of Ginkgo biloba on the reproductive outcome and oxidative stress biomarkers of streptozotocin-induced diabetic rats,” Brazilian Journal of Medical and Biological Research, vol. 40, no. 8, pp. 1095–1099, 2007. View at Google Scholar · View at Scopus
  12. U. J. Eriksson, J. Cederberg, and P. Wentzel, “Congenital malformations in offspring of diabetic mothers—animal and human studies,” Reviews in Endocrine and Metabolic Disorders, vol. 4, no. 1, pp. 79–93, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. D. C. Damasceno, G. T. Volpato, I. D. M. Paranhos Calderon, and M. V. Cunha Rudge, “Oxidative stress and diabetes in pregnant rats,” Animal Reproduction Science, vol. 72, no. 3-4, pp. 235–244, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. U. J. Eriksson, L. A. H. Borg, J. Cederberg et al., “Pathogenesis of diabetes-induced congenital malformations,” Upsala Journal of Medical Sciences, vol. 105, no. 2, pp. 53–84, 2000. View at Google Scholar · View at Scopus
  15. N. Martínez, E. Capobianco, V. White, M. C. Pustovrh, R. Higa, and A. Jawerbaum, “Peroxisome proliferator-activated receptor α activation regulates lipid metabolism in the feto-placental unit from diabetic rats,” Reproduction, vol. 136, no. 1, pp. 95–103, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. N. Triadou, B. Portha, and B. Rosselin, “Experimental chemical diabetes and pregnancy in the rat. Evolution of glucose tolerance and insulin response,” Diabetes, vol. 31, no. 1, pp. 75–79, 1982. View at Google Scholar · View at Scopus
  17. B. Portha, C. Levacher, L. Picon, and G. Rosselin, “Diabetogenic effect of streptozotocin in the rat during the perinatal period,” Diabetes, vol. 23, no. 11, pp. 889–895, 1974. View at Google Scholar · View at Scopus
  18. N. A. Soulimane-Mokhtari, B. Guermouche, A. Yessoufou et al., “Modulation of lipid metabolism by n-3 polyunsaturated fatty acids in gestational diabetic rats and their macrosomic offspring,” Clinical Science, vol. 109, no. 3, pp. 287–295, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. D. C. Damasceno, A. C. I. Kiss, Y. K. Sinzato et al., “Maternal-fetal outcome, lipid profile and oxidative stress of diabetic rats neonatally exposed to streptozotocin,” Experimental and Clinical Endocrinology and Diabetes, vol. 119, no. 7, pp. 408–413, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. K. Tsuji, T. Taminato, M. Usami et al., “Characteristic features of insulin secretion in the streptozotocin-induced NIDDM rat model,” Metabolism, vol. 37, no. 11, pp. 1040–1044, 1988. View at Google Scholar · View at Scopus
  21. I. M. P. Calderon, M. V. C. Rudge, M. D. Ramos et al., “Estudo longitudinal, bioquímico e histoquímico de placentas de ratas diabética-relação com a macrossomia e o retardo de crescimento intrauterino,” Revista Brasileira de Ginecologia e Obstetrícia, vol. 21, pp. 91–98, 1999. View at Google Scholar
  22. K. E. de Campos, Y. K. Sinzato, W. D. P. Pimenta, M. V. C. Rudge, and D. C. Damasceno, “Effect of maternal obesity on diabetes development in adult rat offspring,” Life Sciences, vol. 81, no. 19-20, pp. 1473–1478, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. N. Tietz, Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, Saunders, New York, NY, USA, 4th edition, 2005.
  24. M. M. Tai, “A mathematical model for the determination of total area under glucose tolerance and other metabolic curves,” Diabetes Care, vol. 17, no. 2, pp. 152–154, 1994. View at Google Scholar · View at Scopus
  25. D. C. Damasceno, W. G. Kempinas, G. T. Volpato et al., Anomalias Congênitas: Estudos Experimentais, Coopmed, Belo Horizonte, Brazil, 2008.
  26. M. da Silva Soares de Souza, P. H. O. Lima, Y. K. Sinzato, M. V. C. Rudge, O. C. M. Pereira, and D. C. Damasceno, “Effects of cigarette smoke exposure on pregnancy outcome and offspring of diabetic rats,” Reproductive BioMedicine Online, vol. 18, no. 4, pp. 562–567, 2009. View at Google Scholar · View at Scopus
  27. A. S. Chang, A. N. Dale, and K. H. Moley, “Maternal diabetes adversely affects preovulatory oocyte maturation, development, and granulosa cell apoptosis,” Endocrinology, vol. 146, no. 5, pp. 2445–2453, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. A. Jawerbaum, E. T. Gonzalez, A. Faletti, V. Novaro, A. Vitullo, and M. A. F. Gimeno, “Altered prostanoid production by cumulus-oocyte complexes in a rat model of non-insulin-dependent diabetes mellitus,” Prostaglandins, vol. 52, no. 3, pp. 209–219, 1996. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Spindler-Vomachka and D. C. Johnson, “Altered hypothalamic-pituitary function in the adult female rat with streptozotocin-induced diabetes,” Diabetologia, vol. 28, no. 1, pp. 38–44, 1985. View at Google Scholar · View at Scopus
  30. D. R. Garris, R. L. West, and P. H. Pekala, “Ultrastructural and metabolic changes associated with reproductive tract atrophy and adiposity in diabetic female mice,” Anatomical Record, vol. 216, no. 3, pp. 359–366, 1986. View at Google Scholar · View at Scopus
  31. M. S. Vomachka and D. C. Johnson, “Ovulation, ovarian 17α-hydroxylase activity, and serum concentrations of luteinizing hormone, estradiol, and progesterone in immature rats with diabetes mellitus induced by streptozotocin,” Proceedings of the Society for Experimental Biology and Medicine, vol. 171, no. 2, pp. 207–213, 1982. View at Google Scholar · View at Scopus
  32. R. B. Fraser, S. L. Waite, K. A. Wood, and K. L. Martin, “Impact of hyperglycemia on early embryo development and embryopathy: in vitro experiments using a mouse model,” Human Reproduction, vol. 22, no. 12, pp. 3059–3068, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. A. Jawerbaum, J. Roselló Catafau, E. T. Gonzalez et al., “Eicosanoid production, metabolism and contractile activity in the isolated uterus from non-insulin-dependent diabetic rats during late pregnancy,” Prostaglandins, vol. 51, no. 5, pp. 307–320, 1996. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Jawerbaum, J. Rosello Catafau, E. T. Gonzalez et al., “Glucose metabolism, triglyceride and glycogen levels, as well as eicosanoid production in isolated uterine strips and in embryos in a rat model of non-insulin-dependent diabetes mellitus during pregnancy,” Prostaglandins, vol. 47, no. 2, pp. 81–96, 1994. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Doblado and K. H. Moley, “Glucose metabolism in pregnancy and embryogenesis,” Current Opinion in Endocrinology, vol. 14, no. 6, pp. 488–493, 2007. View at Publisher · View at Google Scholar · View at Scopus
  36. E. A. Reece, D. R. Coustan, and S. G. Gabbe, Diabetes in Women: Adolescence, Pregnancy and Menopause, Lippincott Williams & Wilkins, New York, NY, USA, 2004.
  37. M. V. C. Rudge, “Diabete e gestação,” Femina, vol. 16, pp. 125–148, 1988. View at Google Scholar
  38. U. J. Eriksson, J. Cederberg, and P. Wentzel, “Congenital malformations in offspring of diabetic mothers—animal and human studies,” Reviews in Endocrine and Metabolic Disorders, vol. 4, no. 1, pp. 79–93, 2003. View at Publisher · View at Google Scholar · View at Scopus
  39. T. W. Sadler, E. S. Hunter, W. Balkan, and W. E. Horton, “Effects of maternal diabetes on embryogenesis,” American Journal of Perinatology, vol. 5, no. 4, pp. 319–326, 1988. View at Google Scholar · View at Scopus
  40. N. Freinkel, “Of pregnancy and progeny,” Diabetes, vol. 29, no. 12, pp. 1023–1035, 1980. View at Google Scholar · View at Scopus
  41. L. Jovanovic, R. H. Knopp, H. Kim et al., “Elevated pregnancy losses at high and low extremes of maternal glucose in early normal and diabetic pregnancy: evidence for a protective adaptation in diabetes,” Diabetes Care, vol. 28, no. 5, pp. 1113–1117, 2005. View at Publisher · View at Google Scholar · View at Scopus
  42. J. Aplin, “Maternal influences on placental development,” Seminars in Cell and Developmental Biology, vol. 11, no. 2, pp. 115–125, 2000. View at Publisher · View at Google Scholar · View at Scopus
  43. J. J. Brosens and B. Gellersen, “Death or survival—progesterone-dependent cell fate decisions in the human endometrial stroma,” Journal of Molecular Endocrinology, vol. 36, no. 3, pp. 389–398, 2006. View at Publisher · View at Google Scholar · View at Scopus
  44. K. Y. Lee and F. J. DeMayo, “Animal models of implantation,” Reproduction, vol. 128, no. 6, pp. 679–695, 2004. View at Publisher · View at Google Scholar · View at Scopus
  45. S. M. K. Alam, T. Konno, N. Sahgal, L. Lu, and M. J. Soares, “Decidual cells produce a heparin-binding prolactin family cytokine with putative intrauterine regulatory actions,” Journal of Biological Chemistry, vol. 283, no. 27, pp. 18957–18968, 2008. View at Publisher · View at Google Scholar · View at Scopus
  46. S. C. Bell, “Decidualization and associated cell types: implications for the role of the placental bed in the materno-fetal immunological relationship,” Journal of Reproductive Immunology, vol. 5, no. 4, pp. 185–194, 1983. View at Publisher · View at Google Scholar · View at Scopus
  47. D. R. Garris, “Effects of diabetes on uterine condition, decidualization, vascularization, and corpus luteum function in the pseudopregnant rat,” Endocrinology, vol. 122, no. 2, pp. 665–672, 1988. View at Google Scholar · View at Scopus
  48. M. A. Palomino Garibay, C. Revilla Monsalve, A. Cárdenas Sánchez, A. C. Polanco Ponce, and S. Islas Andrade, “Effect of induced diabetes on reproduction and development,” Ginecología y Obstetricia de México, vol. 66, pp. 403–406, 1998. View at Google Scholar · View at Scopus
  49. M. P. McLean, K. J. Warden, T. W. Sandhoff, R. B. Irby, and D. B. Hales, “Altered ovarian sterol carrier protein expression in the pregnant streptozotocintreated diabetic rat,” Biology of Reproduction, vol. 55, no. 1, pp. 38–46, 1996. View at Google Scholar · View at Scopus