Increased Inflammation in Atherosclerotic Lesions of Diabetic Akita-LDLr^−/− Mice Compared to Nondiabetic LDLr^−/− Mice

Table 2

Plasma cytokine levels in 𝑘𝑖𝑡𝑎-𝐿𝐷𝐿𝑟^−/− mice and control 𝐿𝐷𝐿𝑟^−/− mice at 24 weeks of age.

	IFN𝛾	IL-2	IL-4	IL-5	IL-10	IL-12 (p40 + p70)
Males
𝐴𝑘𝑖𝑡𝑎-𝐿𝐷𝐿𝑟^−/− (𝑛=5-6)	2.0±0.71	21.2±3.2	3.0±1.2	9.7±1.1	104±15.2	978±139^∗
𝐿𝐷𝐿𝑟^−/− (𝑛=7)	2.1±0.87	20.1±3.2	3.0±1.2	9.6±1.7	90.4±19.4	1410±316
Females
𝐴𝑘𝑖𝑡𝑎-𝐿𝐷𝐿𝑟^−/− (𝑛=10)	6.3±7.8	17.9±1.5	12.0±15.9	17.0±8.5	218±229	1290±304
𝐿𝐷𝐿𝑟^−/− (𝑛=7)	10.8±20.1	16.3±3.6	12.4±23.3	14.3±7.4	198±203	1140±305

* 𝑃<0.05 versus 𝐿𝐷𝐿𝑟^−/− males; Bonferroni post-hoc test.
Two-way ANOVA revealed interactions between diabetes and gender for IL-12 (𝑃<0.05), and significant effect of gender for IL-5 (𝑃<0.05).
Values represent mean ± SD.