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Experimental Diabetes Research
Volume 2012, Article ID 179849, 8 pages
http://dx.doi.org/10.1155/2012/179849
Clinical Study

Simple Cystatin C Formula for Estimation of Glomerular Filtration Rate in Overweight Patients with Diabetes Mellitus Type 2 and Chronic Kidney Disease

1Department of Nephrology, Clinic of Internal Medicine, University Medical Center Maribor, 2000 Maribor, Slovenia
2Department of Endocrinology and Diabetology, Clinic of Internal Medicine, University Medical Center Maribor, 2000 Maribor, Slovenia
3Department of Clinical Chemistry, Clinic of Internal Medicine, University Medical Center Maribor, 2000 Maribor, Slovenia
4Department of Nuclear Medicine, Clinic of Internal Medicine, University Medical Center Maribor, 2000 Maribor, Slovenia

Received 18 April 2012; Revised 28 June 2012; Accepted 12 July 2012

Academic Editor: Bernard Portha

Copyright © 2012 Sebastjan Bevc et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In clinical practice the glomerular filtration rate (GFR) is estimated from serum creatinine-based equations like the Cockcroft-Gault formula (C&G) and Modification of Diet in Renal Disease formula (MDRD). Recently, serum cystatin C-based equations, the newer creatinine formula (The Chronic Kidney Disease Epidemiology Collaboration formula (CKD-EPI)), and equation that use both serum creatinine and cystatin C (CKD-EPI creatinine & cystatin formula) were proposed as new GFR markers. Present study compares serum creatinine-based equations, combined (including both serum creatinine and cystatin C) equation, and serum simple cystatin C formula (100/serum cystatin C) against 51CrEDTA clearance in 113 adult overweight Caucasians with diabetes mellitus type 2 (DM2) and chronic kidney disease (CKD). The results of present study demonstrated that the simple cystatin C formula could be a useful tool for the evaluation of renal function in overweight patients with DM2 and impaired kidney function in daily clinical practice in hospital and especially in outpatients. Despite the advantages of the simple cystatin C formula, cystatin C-based equations cannot completely replace the “gold standard” for estimation of the GFR in a population of DM2 patients with CKD, but may contribute to a more accurate selection of patients requiring such invasive and costly procedures.