Glibenclamide Induces Collagen IV Catabolism in High Glucose-Stimulated Mesangial Cells

Figure 1

Gene and protein expression of collagen IV and PAI-1 in rat mesangial cells after chronic exposure (8 weeks) to high glucose with and without treatment with glibenclamide. The PAI-1 assay used reacts with latent, active, and inactive PAI-1. Results were factored by number of cells according to DNA content in the cell layer of the corresponding sample. mRNA 𝑛=17 per experimental group, protein 𝑛=12 per experimental group.

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