Protective Effects of Beta Glucan and Gliclazide on Brain Tissue and Sciatic Nerve of Diabetic Rats Induced by Streptozosin

Table 2

Biochemical parameters in all groups in the sciatic nerve of rats.

Groups	MDA; (nmol/gr protein)	TOS; (mmol H2O2 Eq./g protein)	TAS; (mmol Trolox Eq./g protein)	OSI	Catalase; (U/g protein)	PON-1 activity; (U/mg protein)
Control (I)	17.6±3.1	11.4±3.5	0.16±0.01	70.7±23.0	0.36±0.07	0.11±0.02
Diabetic (II)	30.2±4.2	20.6±1.9	0.08±0.03	299.4±161.9	0.19±0.05	0.04±0.01
Diabetic + gliclazide (III)	25.0±2.9	17.7±2.5	0.11±0.02	162.3±37.2	0.21±0.03	0.06±0.01
Diabetic + Beta glucan (IV)	23.0±1.3	14.1±2.7	0.14±0.03	108.4±41.5	0.29±0.03	0.09±0.03
Gliclazide (V)	16.1±2.4	10.7±3.2	0.16±0.04	71.5±40.8	0.39±0.07	0.12±0.03
Beta glucan (VI)	17.1±3.6	11.3±3.5	0.17±0.04	73.6±45.2	0.38±0.08	0.10±0.03
P values
I-II	0.002	0.004	0.002	0.002	0.002	0.002
II-III	0.017	0.025	N.S.	0.018	N.S.	0.021
II–IV	0.002	0.004	0.012	0.002	0.002	0.006
I–V	N.S.	N.S.	N.S.	N.S.	N.S.	N.S.
I–VI	N.S.	N.S.	N.S.	N.S.	N.S.	N.S.

N.S: not significant, MDA: malondialdehyde, TOS: total oxidant status, TAS: total antioxidant status, OSI: oxidative stress index, PON-1: paraoxonase.