L(+) and D(-) Lactate Are Increased in Plasma and Urine Samples of Type 2 Diabetes as Measured by a Simultaneous Quantification of L(+) and D(-) Lactate by Reversed-Phase Liquid Chromatography Tandem Mass Spectrometry

Table 4

Precision data for D- and L-Lactate in plasma and urine.

Matrix	D-lactate mean (SD), μmol/L	CV,%	L-lactate mean (SD), μmol/L	CV,%
Intra-assay, 𝑛=10
Plasma A	13.0 (0.7)	5.1	1265.3 (36.2)	2.9
Plasma B	85.7 (2.5)	2.9	6605.8 (190.4)	2.9
Interassay, 𝑛=10
Plasma A	12.4 (0.6)	5.2	1338.7 (48.8)	3.6
Plasma B	85.4 (3.8)	4.4	6452.6 (245.8)	3.8
	D-lactate mean (SD), μmol/mmol creatinine		L-lactate mean (SD), μmol/mmol creatinine	CV, %
Intra-assay, 𝑛=10
Urine A^(1)	0.857 (0.03)	3.8	4.40 (0.27)	6.0
Urine B^(2)	16.26 (0.48)	2.9	10.58 (0.60)	5.7
Interassay, 𝑛=10
Urine A^(1)	0.718 (0.04)	5.6	3.75 (0.33)	8.8
Urine B^(2)	14.90 (1.05)	7.0	8.68 (0.81)	9.3

⁽¹⁾Urine A, creatinine 15.4 mmol/L.
⁽²⁾Urine B, creatinine 5.9 mmol/L.