Severe Maternal Hyperglycemia Exacerbates the Development of Insulin Resistance and Fatty Liver in the Offspring on High Fat Diet

Figure 3

Severe maternal hyperglycemia impairs postnatal growth rate in the offspring. (a) Bodyweight gain in CON offspring and STZ offspring from birth to 12 weeks under standard chow diet feeding after weaning, data were mean ± SEM, ^∗𝑃<0.05 versus STZ; (b) bodyweight gain in CON offspring and STZ offspring under standard chow diet or high fat diet feeding from 13 weeks to 25 weeks. CON-S: CON offspring fed with standard chow diet; CON-H: CON offspring fed with high fat diet; STZ-S: STZ offspring fed with standard chow diet; STZ-H: STZ offspring fed with high fat diet. Data were presented as means ± SEM. ^∗𝑃<0.05 versus CON-S, ^#𝑃<0.05 versus STZ-H. 𝑛=6–11 in each group.

(a)

(b)