Severe Maternal Hyperglycemia Exacerbates the Development of Insulin Resistance and Fatty Liver in the Offspring on High Fat Diet
Figure 4
Severe maternal hyperglycemia during gestation and lactation produces metabolic dysfunction only in STZ offspring on HFD. (a) Glucose tolerance test (GTT) at 8 weeks between CON offspring and STZ offspring under standard chow diet feeding. (b) GTT at 24 weeks in CON offspring and STZ offspring under standard chow diet or high fat diet feeding. (c) Insulin tolerance test at 25 weeks in these four groups. (d) Insulin releasing test determined during the GTT. CON-S: CON offspring fed with standard chow diet; CON-H: CON offspring fed with high fat diet; STZ-S: STZ offspring fed with standard chow diet; STZ-H: STZ offspring fed with high fat diet. Data were presented as means ± SEM. versus STZ-S, versus CON-H, in each group.
