Severe Maternal Hyperglycemia Exacerbates the Development of Insulin Resistance and Fatty Liver in the Offspring on High Fat Diet

Table 1

Metabolic parameters of CON offspring and STZ offspring at the age of 25 weeks.

	CON-S	CON-H	STZ-S	STZ-H
Body weight (g)	469.5 ± 20.9	492.7 ± 19.3	418.7 ± 12.6	449.1±19.4^*,#
Sum of WAT(g)	20.9±1.9	27.5±0.8	13.3±0.7	17.6±1.2^*,#
Insulin (ng/ml)	0.23±0.04	0.39±0.04	0.25±0.05	0.42±0.05 *
Leptin (ng/ml)	1.37±0.12	1.95±0.13	1.31±0.21	1.53±0.40
TC (mM)	1.63±0.05	2.27±0.35	1.78±0.37	2.41±0.11 *
TG (mM)	5.32±1.02	4.85±1.07	4.50±2.49	8.15±1.64^*,#
HDL (mM)	0.80±0.10	1.11±0.11	0.77±0.06	0.59±0.08^*,#
LDL (mM)	0.31±0.02	047±0.08	0.37±0.14	0.64±0.06^*,#

Sum of WAT, sum of retroperitoneal and gonadal white adipose tissue; TC: total cholesterol; TG: triglyceride; HDL: high-density lipoprotein; LDL: low-density lipoprotein. CON-S: CON offspring fed with standard chow diet; CON-H: CON offspring fed with high fat diet; STZ-S: STZ offspring fed with standard chow diet; STZ-H: STZ offspring fed with high fat diet. Data were presented as means ± SEM. ^∗𝑃<0.05 versus STZ-S, ^#𝑃<0.05 versus CON-H, 𝑛=6-11 in each group.