Predictors of Impaired Glucose Regulation in Patients with Non-Alcoholic Fatty Liver Disease

Table 1

Baseline characteristics of non-alcoholic fatty liver disease patients with and without hyperglycemia.

Patient characteristics	IFG/IGT, 𝑛=45	DM, 𝑛=29	Hyperglycemia (IFG/IGT or DM), 𝑛=74	Normoglycemia, 𝑛=78	𝑃 value (patients with hyperglycemia versus normoglycemia)
n/N (%) OR mean ± standard deviation
Sex, Female	21/45 (46.7%)	14/29 (48.3%)	35/74 (47.3%)	44/78 (56.4%)	0.26
Age, years	51.2 ± 10.2	55.9 ± 11.0	53.0 ± 10.7	47.3 ± 11.4	<0.01
Body mass index, kg/m^2	30.0 ± 4.2	31.1 ± 4.9	30.5 ± 4.5	28.5 ± 4.8	0.01
AST, U/L	43.7 ± 46.6	38.8 ± 23.5	41.7 ± 38.8	40.2 ± 33.4	0.81
ALT, U/L	64.6 ± 45.9	59.8 ± 39.1	62.7 ± 38.8	67.7 ± 55.6	0.55
AST/ALT ratio	0.68 ± 0.22	0.72 ± 0.30	0.70 ± 0.25	0.71 ± 0.39	0.85
GGT, U/L	86.7 ± 70.8	89.6 ± 87.1	87.9 ± 77.2	86.6 ± 88.7	0.92
Cholesterol, mg/dL	209.4 ± 40.7	209.2 ± 50.8	209.3 ± 44.6	211.9 ± 42.3	0.74
Triglycerides, mg/dL	135.1 ± 64.5	146.4 ± 76.2	139.7 ± 69.1	123.1 ± 72.3	0.18
HDL-C, mg/dL	47.6 ± 14.3	45.0 ± 12.7	46.5 ± 13.6	53.7 ± 18.8	0.02
LDL-C, mg/dL	128.3 ± 32.1	131.2 ± 40.3	129.6 ± 35.8	133.9 ± 34.1	0.51
Triglycerides/HDL-C ratio	3.6 ± 3.4	3.6 ± 2.2	3.6 ± 2.9	2.7 ± 2.2	0.05
Total Protein, g/dL	7.0 ± 1.5	7.0 ± 1.6	7.0 ± 1.5	7.1 ± 1.7	0.83
Albumin, g/dL	4.2 ± 0.4	4.0 ± 0.5	4.1 ± 0.5	4.4 ± 0.4	<0.01
Albumin/globulin ratio	3.1 ± 7.9	1.8 ± 1.7	2.5 ± 6.1	2.3 ± 3.1	0.83
Hemoglobin, g/dL	14.4 ± 1.5	13.6 ± 1.7	14.0 ± 1.6	14.1 ± 1.4	0.93
Hematocrit, %	43.4 ± 4.6	41.8 ± 4.2	42.7 ± 4.5	42.2 ± 3.8	0.45

ALT: alanine aminotransferase, AST: aspartate aminotransferase, DM: type 2 diabetes mellitus, IFG: impaired fasting glucose, IGT: impaired glucose tolerance, GGT: gamma-glutamyl transpeptidase, HDL-C: high-density lipoprotein cholesterol, IFG: impaired fasting glucose, and IGT: impaired glucose tolerance.