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Experimental Diabetes Research
Volume 2012, Article ID 386041, 8 pages
Clinical Study

Investigating Endothelial Activation and Oxidative Stress in relation to Glycaemic Control in a Multiethnic Population

1Department of Diabetes Research, University Hospitals of Leicester, NHS Trust, Leicester LE5 4PW, UK
2Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK
3Department of Health Sciences, University of Leicester, Leicester LE1 6TP, UK
4Unilever Discover, Colworth Science Park, Sharnbrook MK44 ILQ, UK
5BHF Institute for Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, UK

Received 12 July 2012; Revised 16 October 2012; Accepted 9 November 2012

Academic Editor: K. Herbert

Copyright © 2012 E. M. Brady et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. An exploration of ethnic differences in measures of oxidative stress and endothelial activation in relation to known cardiovascular risk factors within South Asians (SA) and White Europeans (WE) residing in the UK. Methods. 202 participants within a UK multiethnic population provided biomedical and anthropometric data. Human urinary 2,3-dinor-8-iso-prostaglandin-F1α and plasma ICAM-1 were quantified as measures of oxidative stress and endothelial activation, respectively. Results. 2,3-Dinor-8-iso-prostaglandin-F1α levels were significantly higher in the SA group compared to WE group (10.36 (95% CI: 9.09, 11.79) versus 8.46 (7.71, 9.29), ) after adjustment for age, gender, smoking status, body weight, HbA1c, and medication. Oxidative stress was positively associated with HbA1c ( , 95% CI:1.02, 1.14, ), fasting , 95% CI: 1.02, 1.10, ), and 2 hr glucose ( , 95% CI: 1.00, 1.04, ). In each adjusted model, SA continued to have elevated levels of oxidative stress compared to WE. ICAM-1 levels were significantly higher in the composite IGR group compared to the normoglycaemic group ( ). No ethnic differences in ICAM-1 were observed. Conclusion. These results suggest that SA are more susceptible to the detrimental effects of hyperglycaemia-induced oxidative stress at lower blood glucose thresholds than WE. Further research into the potential mechanisms involved is warranted.