Differential Changes of Aorta and Carotid Vasodilation in Type 2 Diabetic GK and OLETF Rats: Paradoxical Roles of Hyperglycemia and Insulin
Aorta responses to acetylcholine (ACh) and phenylephrine (PE) in the presence of nitric oxide synthase blocker, -nitro-L-arginine methyl ester (L-NAME) or heme oxygenase blocker, protoporphyrin IX Zinc (II) (ZnPPIX) in OLETF: Otsuka Long-Evans Tokushima Fatty rat; LETO: Long-Evans Tokushima Otsuka rat; GK: Goto-Kakizaki rat. (a) representative tracings of vessel tension in 3-month-old OLETF and 12-month-old GK, respectively. (b) Relaxation of 12-month-old rat aorta rings to 1 μmol/L ACh before and after NOS and/or HO blockade. Data are mean ± SEM, segments. ** versus respective controls.
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