Differential Changes of Aorta and Carotid Vasodilation in Type 2 Diabetic GK and OLETF Rats: Paradoxical Roles of Hyperglycemia and Insulin

Figure 4

Aorta responses to acetylcholine (ACh) and phenylephrine (PE) in the presence of nitric oxide synthase blocker, 𝑁^𝜔-nitro-L-arginine methyl ester (L-NAME) or heme oxygenase blocker, protoporphyrin IX Zinc (II) (ZnPPIX) in OLETF: Otsuka Long-Evans Tokushima Fatty rat; LETO: Long-Evans Tokushima Otsuka rat; GK: Goto-Kakizaki rat. (a) representative tracings of vessel tension in 3-month-old OLETF and 12-month-old GK, respectively. (b) Relaxation of 12-month-old rat aorta rings to 1 μmol/L ACh before and after NOS and/or HO blockade. Data are mean ± SEM, 𝑛=10-12 segments. **𝑃<0.01 versus respective controls.

(a)

(b)