Hepatic Mitochondrial Alterations and Increased Oxidative Stress in Nutritional Diabetes-Prone Psammomys obesus Model

Table 2

Effect of dietary treatment on respiratory control ratios (RCR) of liver mitochondria from both Psammomys groups. *P < 0.05 versus control group.

		Oxygen consumption rate (natoms O/min/mg protein)
	Glutamate/Malate (GM)			Succinate/Malate (SM) + rotenone
	State 3	State 4	RCR	State 3	State 4	RCR
Control	138.8 ± 9.9	14.8 ± 0.6	9.4 ± 0.9	143.1 ± 5.3	39.3 ± 3.0	3.7 ± 0.3
Diabetic	96.1 ± 7.3*	14.5 ± 0.6	6.6 ± 0.2*	133.0 ± 12.3	35.4 ± 3.5	3.8 ± 0.2